Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F12%3A00383182" target="_blank" >RIV/86652036:_____/12:00383182 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbabio.2012.05.005" target="_blank" >http://dx.doi.org/10.1016/j.bbabio.2012.05.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbabio.2012.05.005" target="_blank" >10.1016/j.bbabio.2012.05.005</a>

Result language
angličtina
Original language name
Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue
Original language description
The effects of alpha-tocopheryl succinate (alpha-TOS), alpha-tocopheryl acetyl ether (alpha-TEA) and triphenylphosphonium-tagged vitamin E succinate (mitochondrially targeted vitamin E succinate; MitoVES) on energy-related mitochondrial functions were determined in mitochondria isolated from AS-30D hepatoma and rat liver, bovine heart sub-mitochondrial particles (SMPs), and in rodent and human carcinoma cell lines and rat hepatocytes. In isolated mitochondria, MitoVES stimulated basal respiration and ATP hydrolysis, but inhibited net state 3 (ADP-stimulated) respiration and Ca2+ uptake, by collapsing the membrane potential at low doses (1-10 mu M). Uncoupled mitochondrial respiration and basal respiration of SMPs were inhibited by the three drugs at concentrations at least one order of magnitude higher and with different efficacy: MitoVES> alpha-TEA>alpha-TOS. At high doses (>10 mu M), the respiratory complex II (CII) was the most sensitive MitoVES target. Acting as an uncoupler at low
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/GAP301%2F10%2F1937" target="_blank" >GAP301/10/1937: Mechanisms of efficient killing of cancer stem cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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