The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00457718" target="_blank" >RIV/67985823:_____/15:00457718 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria

Original language description

We compared the effect of alpha-tocopheryl succinate (TOS) onnsuccinate-dependent respiration in rat liver mitochondria,nhomogenate and permeabilized hepatocytes in both a couplednand uncoupled state. In isolated mitochondria, a significantninhibitory effect was observed at a concentration of 5 ?M, in livernhomogenate at 25 ?M and in permeabilized hepatocytes atn50 ?M. The inhibitory effect of TOS on succinate respiration in annuncoupled state was less pronounced than in a coupled state innall the experimental models tested. When the concentrationndependence of the TOS inhibitory effect was tested, the mostnsensitive in both states were isolated mitochondria; the mostnresistant were permeabilized hepatocytesn

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Suppl.5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

"S609"-"S615"

UT code for WoS article

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EID of the result in the Scopus database

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