The Effect of ?-Tocopheryl Succinate on Succinate Respiration in Rat Liver Mitochondria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10315203" target="_blank" >RIV/00216208:11150/15:10315203 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Effect of ?-Tocopheryl Succinate on Succinate Respiration in Rat Liver Mitochondria

Original language description

We compared the effect of ?-tocopheryl succinate (TOS) on succinate-dependent respiration in rat liver mitochondria, homogenate and permeabilized hepatocytes in both a coupled and uncoupled state. In isolated mitochondria, a significant inhibitory effectwas observed at a concentration of 5 ?M, in liver homogenate at 25 ?M and in permeabilized hepatocytes at 50 ?M. The inhibitory effect of TOS on succinate respiration in an uncoupled state was less pronounced than in a coupled state in all the experimental models tested. When the concentration dependence of the TOS inhibitory effect was tested, the most sensitive in both states were isolated mitochondria; the most resistant were permeabilized hepatocytes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Suppl. 5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

"S609"-"S615"

UT code for WoS article

000372421900007

EID of the result in the Scopus database

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