Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00431276" target="_blank" >RIV/61388963:_____/14:00431276 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/14:00431276

Result on the web

<a href="http://dx.doi.org/10.1179/1351000213Y.0000000064" target="_blank" >http://dx.doi.org/10.1179/1351000213Y.0000000064</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1179/1351000213Y.0000000064" target="_blank" >10.1179/1351000213Y.0000000064</a>

Result language

angličtina

Original language name

Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy

Original language description

Malignant mesothelioma (MM) is a fatal neoplastic disease with no therapeutic option. Therefore, the search for novel therapies is of paramount importance. Methods: Since mitochondrial targeting of alpha-tocopheryl succinate (alpha-TOS) by its tagging with triphenylphosphonium enhances its cytotoxic effects to cancer cells, we tested its effect on MM cells and experimental mesotheliomas. Results: Mitochondrially targeted vitamin E succinate (MitoVES) was more efficient in killing MM cells than a-TOS with IC50 lower by up to two orders of magnitude. Mitochondrial association of MitoVES in MM cells was documented using its fluorescently tagged analogue. MitoVES caused apoptosis in MM cells by mitochondrial destabilization, resulting in the loss of mitochondrial membrane potential, generation of reactive oxygen species, and destabilization of respiratory supercomplexes. The role of the mitochondrial complex II in the activity of MitoVES was confirmed by the finding that MM cells with supp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Redox Report

ISSN

1351-0002

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

16-25

UT code for WoS article

000337129600003

EID of the result in the Scopus database

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