Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to alpha-tocopheryl succinate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00392315" target="_blank" >RIV/61388963:_____/13:00392315 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/13:00392315 RIV/00027162:_____/13:#0000989

Result on the web

<a href="http://dx.doi.org/10.1007/s10495-012-0795-1" target="_blank" >http://dx.doi.org/10.1007/s10495-012-0795-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10495-012-0795-1" target="_blank" >10.1007/s10495-012-0795-1</a>

Result language

angličtina

Original language name

Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to alpha-tocopheryl succinate

Original language description

alpha-Tocopheryl succinate (alpha-TOS) is a promising anti-cancer agent due to its selectivity for cancer cells. It is important to understand whether long-term exposure of tumour cells to the agent will render them resistant to the treatment. Exposure of the non-small cell lung carcinoma H1299 cells to escalating doses of alpha-TOS made them resistant to the agent due to the upregulation of the ABCA1 protein, which caused its efflux. Full susceptibility of the cells to alpha-TOS was restored by knocking down the ABCA1 protein. Similar resistance including ABCA1 gene upregulation was observed in the A549 lung cancer cells exposed to alpha-TOS. The resistance of the cells to alpha-TOS was overcome by its mitochondrially targeted analogue, MitoVES, thatis taken up on the basis of the membrane potential, bypassing the enhanced expression of the ABCA1 protein. The in vitro results were replicated in mouse models of tumours derived from parental and resistant H1299 cells. We conclude that

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Apoptosis

ISSN

1360-8185

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

286-299

UT code for WoS article

000315086000004

EID of the result in the Scopus database

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