Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F06%3A00051235" target="_blank" >RIV/68378050:_____/06:00051235 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells
Original language description
mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by alpha-tocopheryl succinate (alpha-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to alpha-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to alpha-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to alpha-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties.
Czech name
Role thioredoxinu-1 v apoptóze indukované alfa-tokoferylsukcinátem a apoptózu-indukujícím ligandem příbuzným TNF v mesoteliomálních buňkách
Czech description
Maligní mesoteliom (MM) představuje fatální typ rakoviny. Studovali jsme úlohu redoxně aktivního proteinu thioredoxinu-1 (Trx-1) v apoptóze, která byla indukována v MM buňkách a v jejich nezhoubných protějšcích (Met-5A) alfa-tokoferylsukcinátem (alfa-TOS) a apoptózu indukujícím ligandem příbuzným TNF (TRAIL). MM buňky byly citlivé k alfa TOS a méně k TRAIL, zatímco Met-5A buňky byly citlivé k TRAIL a resistentní
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
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Volume of the periodical
580
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
2671-2676
UT code for WoS article
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EID of the result in the Scopus database
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