Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F06%3A00047784" target="_blank" >RIV/68378050:_____/06:00047784 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
Original language description
We evaluated the ability of alpha-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishessensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal dosesof a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli.
Czech name
Alfa-tokoferol sukcinát vyvolává expresi DR4 a DR5 cestou závislou na p53: implikace pro sensitizaci rezistentních nádorových buněk k apoptóze vyvolané prostřednictvím TRAIL
Czech description
Alfa-tokoferol sukcinát (vitamin E sukcinát, a-TOS) zvyšuje citlivost mesotheliomálních nádorových buněk k apoptóze indukované cytotoxickým ligandem TRAIL. a-TOS zvyšuje expresi proapoptotických TRAILových receptorů DR4/DR5 v závislosti na p53. Mesotheliomální buňky rezistentní k TRAILu mají nízkou expresi DR4/DR5, kterou lze zvýšit předinkubací se subletálními dávkami a-TOS.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
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Volume of the periodical
580
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1925-1931
UT code for WoS article
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EID of the result in the Scopus database
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