alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F10%3A%230000624" target="_blank" >RIV/00027162:_____/10:#0000624 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/10:00349091

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

Original language description

Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and generate reactive oxygen species (ROS). However, the molecular events by which ROS production leads to apoptosis has not been clearly defined. In this study with the mitocan alpha-tocopheryl succinate (alpha-TOS) the role of the Bcl-2 family proteins in the mechanism of malignant cell apoptosis has been determined. Exposure of several different cancer cell lines to alpha-TOS caused a profound conformational change in the pro-apoptotic protein, Bak, involving oligomerization in all cell types tested. Bak forms high molecular weight complexes in the mitochondria upon alfa-TOS treatment. We conclude that the major events induced by alpha-TOS in cancer cells downstream ofROS production leading to mitochondrial apoptosis involve the Noxa-Bak axis. It is proposed that this represents a common mechanism for mitochondrial destabilization activated by a variety of mitocans that induce accumulation of ROS.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Apoptosis

ISSN

1360-8185

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

7

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

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UT code for WoS article

000279190700003

EID of the result in the Scopus database

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