The effect of mitochondrially targeted anticancer agents on mitochondrial (super)complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F15%3A00522123" target="_blank" >RIV/86652036:_____/15:00522123 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/protocol/10.1007%2F978-1-4939-2288-8_15" target="_blank" >https://link.springer.com/protocol/10.1007%2F978-1-4939-2288-8_15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4939-2288-8_15" target="_blank" >10.1007/978-1-4939-2288-8_15</a>
Alternative languages
Result language
angličtina
Original language name
The effect of mitochondrially targeted anticancer agents on mitochondrial (super)complexes
Original language description
The mitochondrial respiratory chain is organized into dynamic high molecular weight complexes that associate to form supercomplexes. The function of these SCs is to minimize the production of reactive oxygen species (ROS) generated during electron transfer within them and to efficiently transfer electrons to complex IV. These supra-molecular structures as well as whole mitochondria are stress-responsive and respond to mitochondrially targeted anti-cancer agent by destabilization and induction of massive production of ROS leading to apoptosis. We have recently developed mitochondrially targeted anti-cancer agents epitomized by the mitochondrially targeted analogue of the redox-silent compound vitamin E succinate, which belongs to the group of agents that kill cancer cells via their mitochondria-destabilizing activity, referred to as mitocans. To understand the molecular mechanism of the effect of such agents, the use of native blue gel electrophoresis and clear native electrophoresis coupled with in-gel activity assays, are methods of choice. The relevant methodology is described in this chapter.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Methods in molecular biology
ISSN
1940-6029
e-ISSN
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Volume of the periodical
1265
Issue of the periodical within the volume
2015
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
195-208
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-84958608088