Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920115" target="_blank" >RIV/00216208:11120/20:43920115 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10411640
Result on the web
<a href="https://doi.org/10.3390/ijms21083005" target="_blank" >https://doi.org/10.3390/ijms21083005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21083005" target="_blank" >10.3390/ijms21083005</a>
Alternative languages
Result language
angličtina
Original language name
Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus
Original language description
This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by internal molecular feedback loops that synchronize the organism with the external environment. These loops are affected by genetic and epigenetic factors. Genetic factors include polymorphisms and mutations of circadian genes. The expression of circadian genes is regulated by epigenetic mechanisms that change from prenatal development to old age. Epigenetic modifications are influenced by the external environment. Most of these modifications are affected by our own life style. Irregular circadian rhythm and low quality of sleep have been shown to increase the risk of developing T2DM and other metabolic disorders. Here, we attempt to provide a wide description of mutual relationships between epigenetic regulation, circadian rhythm, aging process and highlight new evidences that show possible therapeutic advance in the field of chrono-medicine which will be more important in the upcoming years.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
—
Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
"Article 3005"
UT code for WoS article
000535565300347
EID of the result in the Scopus database
2-s2.0-85083883544