Glutamate Transporters (EAAT-1-3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920497" target="_blank" >RIV/00216208:11120/20:43920497 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/20:43920300
Result on the web
<a href="https://doi.org/10.1007/s11055-020-00965-4" target="_blank" >https://doi.org/10.1007/s11055-020-00965-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11055-020-00965-4" target="_blank" >10.1007/s11055-020-00965-4</a>
Alternative languages
Result language
angličtina
Original language name
Glutamate Transporters (EAAT-1-3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy
Original language description
Epilepsy is one of the commonest neurological diseases, though convulsive seizures cannot be completely cured in 30% of patients, such that there is a need to develop new pharmacological approaches to its treatment. In some pathological states, including drug-resistant forms of epilepsy, the mechanisms removing glutamate from the synaptic cleft may be impaired, so one potential approach to these pathological states may be associated with actions on glutamate transporters. The present review analyzes contemporary data on changes in the expression of excitatory amino acid transporter proteins (EAAT) in human epilepsy and in animal models of convulsive states and epilepsy. Mechanisms of actions on the expression and activity of transporters as potential therapeutic targets for the treatment of convulsive states are considered, special attention being paid to analysis of the use of the antibiotic ceftriaxone, which increases the expression and activity of EAAT-2.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience and Behavioral Physiology
ISSN
0097-0549
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
777-786
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85090215720