Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920498" target="_blank" >RIV/00216208:11120/20:43920498 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11510/20:10415974 RIV/00064173:_____/20:N0000040
Result on the web
<a href="https://doi.org/10.1210/clinem/dgaa630" target="_blank" >https://doi.org/10.1210/clinem/dgaa630</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/clinem/dgaa630" target="_blank" >10.1210/clinem/dgaa630</a>
Alternative languages
Result language
angličtina
Original language name
Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial
Original language description
CONTEXT: Metabolic disturbances and a pro-inflammatory state associated with aging and obesity may be mitigated by physical activity or nutrition interventions. OBJECTIVE: The aim of this study is to assess whether physical fitness/exercise training (ET) alleviates inflammation in adipose tissue (AT), particularly in combination with omega-3 supplementation, and whether changes in AT induced by ET can contribute to an improvement of insulin sensitivity (IS) and metabolic health in the elderly. DESIGN, PARTICIPANTS, MAIN OUTCOME MEASURES: The effect of physical fitness was determined in cross-sectional comparison of Trained and Untrained older women (71+-4 years, n=48); and in double-blind randomized intervention by 4 months of ET with or without omega-3 (Calanus oil) supplementation (n=55). Physical fitness was evaluated by Spiroergometry (maximum graded exercise test) and Senior Fitness Tests. IS was measured by hyperinsulinemic-euglycemic clamp. Samples of subcutaneous AT were used to analyze mRNA gene expression, cytokine secretion and immune cell populations. RESULTS: Trained women had lower mRNA levels of inflammation and oxidative stress markers, lower relative content of CD36+ macrophages and higher relative content of γδT-cells in AT when compared to Untrained women. Similar effects were recapitulated in response to a 4-month ET intervention. Content of CD36+ cells, γδT-cells and mRNA expression of several inflammatory and oxidative-stress markers correlated to IS and cardiorespiratory fitness. CONCLUSIONS: In older women, physical fitness is associated with less inflammation in AT. This may contribute to beneficial metabolic outcomes achieved by ET. When combined with ET, omega-3 supplementation had no additional beneficial effects on AT inflammatory characteristics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV16-29182A" target="_blank" >NV16-29182A: Effect of EXercise training and Omega-3 fatty acids on metabolic health and DYsfunction of Adipose tissue in elderly</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Endocrinology & Metabolism
ISSN
0021-972X
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
"e4510"-"e4526"
UT code for WoS article
000584547800059
EID of the result in the Scopus database
2-s2.0-85092682327