The Gold Standard of Thyroid Nodule Examination? Prospective Validation of the ACR TI-RADS in a Secondary Referral Center
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920762" target="_blank" >RIV/00216208:11120/20:43920762 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/20:N0000025 RIV/00064173:_____/20:N0000043
Result on the web
<a href="https://doi.org/10.33549/physiolres.934515" target="_blank" >https://doi.org/10.33549/physiolres.934515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934515" target="_blank" >10.33549/physiolres.934515</a>
Alternative languages
Result language
angličtina
Original language name
The Gold Standard of Thyroid Nodule Examination? Prospective Validation of the ACR TI-RADS in a Secondary Referral Center
Original language description
The aim of this prospective study was the validation of the risk stratification of thyroid nodules using ultrasonography with the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR TI-RADS) and partly in comparison to American Thyroid Association (ATA) guidelines in a secondary referral center. Fine needle aspiration biopsy (FNA) (n=605) and histological examinations (n=63) were the reference standards for the statistical analysis. ACR TI-RADS cut-off value: TR4 with sensitivity 85.7 %, specificity 54.1 %, PPV 58.5 %, accuracy 67.7 % (AUC 0.738; p<0.001). ATA cut-off value: "high suspicion" with sensitivity 80 %, specificity 83.3 %, PPV 80 %, accuracy 81.8 % (AUC 0.800; p=0.0025). 18.4 % nodules (3 malignant) could not be assigned to a proper ATA US pattern group (p<0.0001). Both ACR TI-RADS and ATA have allowed fair selection of nodules requiring FNA with superiority of ACR TI-RADS according to classification of all thyroid nodules to the proper group. According to ACR TI-RADS almost one third of the patients were incorrectly classified with 17.9 % missed thyroid carcinomas, exclusively micropapillary carcinomas, even though, the amount of FNA would be reduced to 48 %.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
Suppl. 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
"S329"-"S337"
UT code for WoS article
000581646000017
EID of the result in the Scopus database
2-s2.0-85094625186