Secretory carcinoma of salivary type in a lymph node presenting as a neck cyst diagnosed by cytology: A case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43920298" target="_blank" >RIV/00216208:11120/21:43920298 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10412887 RIV/00064165:_____/21:10412887 RIV/00064173:_____/21:N0000143
Result on the web
<a href="https://doi.org/10.1002/dc.24550" target="_blank" >https://doi.org/10.1002/dc.24550</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/dc.24550" target="_blank" >10.1002/dc.24550</a>
Alternative languages
Result language
angličtina
Original language name
Secretory carcinoma of salivary type in a lymph node presenting as a neck cyst diagnosed by cytology: A case report
Original language description
Secretory carcinoma (SC) is a relatively recently described salivary gland adenocarcinoma characterized by ETV6-NTRK3 gene fusion and, in most cases, indolent clinical behavior. Morphologically, the tumor shows a glandular architecture and the presence of monophasic tumor cells with vacuolated cytoplasm, low-grade nuclear atypia, and mucin production, with possibly a tubular, papillary, or cystic arrangement. In this article, we describe a case of a 52-year old man with SC involving a neck lymph node clinically manifesting as a slowly growing cystic neck mass without recent proof of the primary tumor, but with a history of a parotid gland "cystadenopapilloma," which had been removed 35 years prior. A fine-needle aspiration biopsy revealed a diagnosis of SC. Subsequent histopathological examination after lymph node dissection confirmed the diagnosis. The tumor showed typical features of SC, including immunohistochemical positivity for NTRK and NTRK3 gene rearrangement, detected using in situ hybridization. We discuss that the tumor may be a late metastasis occurring 35 years after resection of undiagnosed salivary SC or a primary SC arising from heterotopic salivary tissue within a lymph node. Differential diagnostic considerations and review of relevant literature are included.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostic Cytopathology
ISSN
8755-1039
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"e1"-"e6"
UT code for WoS article
000550399200001
EID of the result in the Scopus database
2-s2.0-85088160270