The effect of warfarin administration on platelet aggregation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921582" target="_blank" >RIV/00216208:11120/21:43921582 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/21:00013434 RIV/00064173:_____/21:N0000083
Result on the web
<a href="https://doi.org/10.4149/BLL_2021_054" target="_blank" >https://doi.org/10.4149/BLL_2021_054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2021_054" target="_blank" >10.4149/BLL_2021_054</a>
Alternative languages
Result language
angličtina
Original language name
The effect of warfarin administration on platelet aggregation
Original language description
BACKGROUND: The aim of this study was to assess the effect of anticoagulation treatment on platelet aggregation. METHODS: The study group consisted of 24 patients on long-term warfarin therapy without any antiaggregation therapy. Platelet aggregation was measured using VerifyNow with arachidonic acid (AA) as an inducer in 23 patients and with light transmission aggregometry (LTA) in 19 patients using four different agonists. All patients had their international normalized ratio (INR) checked regularly. RESULTS: The mean INR value was 2.07 (SD 0.6). The average aggregation measured by VerifyNow was found to be 637.5 (SD 36.6) aspirin reaction units. The values of average aggregability in LTA were 73.3 % (SD 4.5 %), 73.2 % (SD 6 %) and 72.1 % (SD 4.8 %) in case of aggregation induced by AA, ADP, and collagen, respectively. Epinephrine-induced aggregability was 65.3 % (SD 14.7 %). Regression analysis between INR and values of collagen-or epinephrine-induced aggregability (r = 0.654 and 0.575) was found statistically significant (p = 0.004 and 0.016); every increase in INR by 0,1 brings about an increase in collagen-and epinephrine-induced aggregation values by 1.5 and 4, respectively. CONCLUSION: Administration of warfarin does not produce a significant reduction in platelet aggregation. On the contrary, prolonged INR evokes a mild increase in aggregation induced by collagen or epinephrine (Tab. 2, Fig. 3, Ref. 32). Text in PDF www.elis.sk
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské lekárske listy / Bratislava Medical Journal
ISSN
0006-9248
e-ISSN
—
Volume of the periodical
122
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
320-324
UT code for WoS article
000647174500005
EID of the result in the Scopus database
2-s2.0-85104312569