Genome of Helicobacter pylori and Serotype of HPV Detected in Oropharyngeal and Laryngeal Cancer and Chronic Inflammation Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43922181" target="_blank" >RIV/00216208:11120/21:43922181 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10431579 RIV/61383082:_____/21:00001045 RIV/00064203:_____/21:10431579

Result on the web

<a href="https://doi.org/10.3390/ijerph18189545" target="_blank" >https://doi.org/10.3390/ijerph18189545</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijerph18189545" target="_blank" >10.3390/ijerph18189545</a>

Result language

angličtina

Original language name

Genome of Helicobacter pylori and Serotype of HPV Detected in Oropharyngeal and Laryngeal Cancer and Chronic Inflammation Patients

Original language description

Objective: Oropharyngeal/laryngeal carcinoma are common cancers of the upper aerodi-gestive system. Human papillomavirus (HPV) is described as the most frequent in the cancer of unknown primary. The presence of Helicobacter pylori (HP) in the oral cavity is discussed in some papers. The aim of study: To analyze the incidence of HPV and HP in oropharyngeal/laryngeal cancer persons versus persons with chronic tonsillar inflammation and healthy persons. Methods: The samples were taken in three groups: (1) tissue of oropharynx/larynx cancer (103 specimens); (2) tissue of palatine tonsils (85 specimens); and (3) healthy control group (50 specimens). We analyzed the presence of HP (PCR) and HPV genomic DNA (Sacace HPV High-Risk Screen Real-TM Quant) in the samples. Results: HP was detected in 86 samples (83.5%) and high-risk HPV in 62 samples (60.2%). We found a very high incidence of HP. In the cancer group, HP was detected in 82.5% cases and HPV positivity in 57.8%. In total, 7.2% of the cancer patients were negative for HP and HPV together. In turn, 53.6% of the cancer patients were positive for HP and HPV together. Four cases (4.2%) were positive for HPV only. VacA positivity was detected in 82 (79.6%) of the cancer cases and VacA negativity in 21 (20.4%) if the cancer cases. The incidence of HP in chronic inflammation (n = 85) was 65 cases (76.5%) and the incidence of HPV was 38 cases (44.7%). VacA positivity was detected in 59 (69.4%) of the chronic inflammation cases and VacA negativity was found in 26 (30.6%) of the chronic inflammation cases. Regarding the control group, we found HP positivity in 5 cases (11.1%) and HPV positivity in 19 cases (42.2%). There was VacA positivity in 6 cases (50.0%) of the control group. Statistically significantly lower prevalence of HP (p &lt; 0.001) and HPV (p = 0.006) was found in the control group. Conclusions: We suggest that the palatine tonsils are colonized by HP. In our study, HP was present in oropharyngeal cancer in more cases in comparison with HPV infection. The presence of VacA from HP can have an influence on the human epithelial and immune cells&apos; regulation ways. Our results do not support idea that the CagA-positive HP is a primary carcinogen in oropharyngeal area.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30206 - Otorhinolaryngology

Project

<a href="/en/project/NT11523" target="_blank" >NT11523: Correlation of Helicobacter pylori and gastroesophageal rephlux to etiopathogenesis of oropharyngeal and laryngeal tumors</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Environmental Research and Public Health

ISSN

1660-4601

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

18

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

9545

UT code for WoS article

000700963500001

EID of the result in the Scopus database

2-s2.0-85114616477