Lactic acidosis in patients with solid cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43923230" target="_blank" >RIV/00216208:11120/22:43923230 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1089/ars.2021.0267" target="_blank" >https://doi.org/10.1089/ars.2021.0267</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/ars.2021.0267" target="_blank" >10.1089/ars.2021.0267</a>
Alternative languages
Result language
angličtina
Original language name
Lactic acidosis in patients with solid cancer
Original language description
Significance Tissue-specific lactic acidosis in cancer stimulates and mediates tumor invasion and metastasis and is druggable. Rarely, malignancy causes systemic lactic acidosis, the role of which is poorly understood. Recent advances The understanding of the role of lactate has shifted dramatically since its discovery. Long recognized as only a waste product, lactate has become known as an alternative metabolism substrate and secreted nutrient that is exchanged between the tumor and the microenvironment. Tissue-specific lactic acidosis is targeted to improve the host body's anticancer defense and serves as a tool that allows the targeting of anticancer compounds. Systemic lactic acidosis is associated with poor survival. In patients with solid cancer, systemic lactic acidosis is associated with an extremely poor prognosis, as revealed by the analysis of 57 published cases in this study. Although it is considered a pathology worth treating, targeting systemic lactic acidosis in patients with solid cancer is usually inefficient. Critical issues Research gaps include simple questions, such as the unknown nuclear pH of the cancer cells and its effects on chemotherapy outcomes, pH sensitivity of glycosylation in cancer cells, in vivo mechanisms of response to acidosis in the absence of lactate, and overinterpretation of in vitro results that were obtained using cells that were not preadapted to acidic environments. Future directions Numerous metabolism-targeting anticancer compounds induce lactatemia, lactic acidosis or other types of acidosis. Their potential to induce acidic environments is largely overlooked, although these compounds might contribute to a substantial portion of the observed clinical effects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants & Redox Signaling
ISSN
1523-0864
e-ISSN
1557-7716
Volume of the periodical
37
Issue of the periodical within the volume
16-18
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
1130-1152
UT code for WoS article
000810230000001
EID of the result in the Scopus database
2-s2.0-85138702256