Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43925641" target="_blank" >RIV/00216208:11120/23:43925641 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.jacc.2023.05.006" target="_blank" >https://doi.org/10.1016/j.jacc.2023.05.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jacc.2023.05.006" target="_blank" >10.1016/j.jacc.2023.05.006</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy
Original language description
BACKGROUND: Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well-established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and wide QRS or expected frequent ventricular pacing. Left bundle branch area pacing (LBBAP) has recently been shown to be a safe alternative to BVP. OBJECTIVE: The aim of this study was to compare the clinical outcomes between BVP and LBBAP among patients undergoing CRT. METHODS: This observational study included patients with LVEFLESS-THAN OR EQUAL TO35% who underwent BVP or LBBAP for the first time for Class I or II indications for CRT between Jan 2018 to June 2022 at 15 international centers. The primary outcome was the composite endpoint of time to death or heart failure hospitalization (HFH). Secondary outcomes included endpoints of death, HFH, and echocardiographic changes. . RESULTS: A total of 1778 patients met inclusion criteria: BVP 981, LBBAP 797. The mean age was 69+-12 years, female 32%, CAD 48%, and LVEF 27+-6%. Paced QRSd in LBBAP was significantly narrower than baseline (128+-19 vs 161+-28ms, p<0.001) and significantly narrower compared to BVP (144+-23ms, p<0.001). Following CRT, LVEF improved from 27+-6% to 41+-13% (p<0.001) with LBBAP compared to an increase from 27+-7% to 37+-12% (p<0.001) with BVP with significantly greater change from baseline with LBBAP (13+-12% vs 10+-12%, p<0.001). On multivariable regression analysis, the primary outcome was significantly reduced with LBBAP compared BVP (20.8% vs 28%; HR 1.495; CI 1.213-1.842; p<0.001). CONCLUSIONS: LBBAP improved clinical outcomes when compared to BVP in patients with CRT indications and may be a reasonable alternative to BVP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the American College of Cardiology
ISSN
0735-1097
e-ISSN
1558-3597
Volume of the periodical
82
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
228-241
UT code for WoS article
001041062200001
EID of the result in the Scopus database
2-s2.0-85163010359