Left bundle branch area pacing results in more physiological ventricular activation than biventricular pacing in patients with left bundle branch block heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F23%3A00572954" target="_blank" >RIV/68081731:_____/23:00572954 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43925635 RIV/00064173:_____/23:43925635 RIV/00159816:_____/23:00079603

Result on the web

<a href="https://academic.oup.com/eurheartjsupp/article/25/Supplement_E/E17/7174252" target="_blank" >https://academic.oup.com/eurheartjsupp/article/25/Supplement_E/E17/7174252</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartjsupp/suad109" target="_blank" >10.1093/eurheartjsupp/suad109</a>

Result language

angličtina

Original language name

Left bundle branch area pacing results in more physiological ventricular activation than biventricular pacing in patients with left bundle branch block heart failure

Original language description

Biventricular pacing (Biv) and left bundle branch area pacing (LBBAP) are methods of cardiac resynchronization therapy (CRT). Currently, little is known about how they differ in terms of ventricular activation. This study compared ventricular activation patterns in left bundle branch block (LBBB) heart failure patients using an ultra-high-frequency electrocardiography (UHF-ECG). This was a retrospective analysis including 80 CRT patients from two centres. UHF-ECG data were obtained during LBBB, LBBAP, and Biv. Left bundle branch area pacing patients were divided into non-selective left bundle branch pacing (NSLBBP) or left ventricular septal pacing (LVSP) and into groups with V6 R-wave peak times (V6RWPT) < 90 ms and ≥ 90 ms. Calculated parameters were: e-DYS (time difference between the first and last activation in V1-V8 leads) and Vdmean (average of V1-V8 local depolarization durations). In LBBB patients (n = 80) indicated for CRT, spontaneous rhythms were compared with Biv (39) and LBBAP rhythms (64). Although both Biv and LBBAP significantly reduced QRS duration (QRSd) compared with LBBB (from 172 to 148 and 152 ms, respectively, both P < 0.001), the difference between them was not significant (P = 0.2). Left bundle branch area pacing led to shorter e-DYS (24 ms) than Biv (33 ms, P = 0.008) and shorter Vdmean (53 vs. 59 ms, P = 0.003). No differences in QRSd, e-DYS, or Vdmean were found between NSLBBP, LVSP, and LBBAP with paced V6RWPTs < 90 and ≥ 90 ms. Both Biv CRT and LBBAP significantly reduce ventricular dyssynchrony in CRT patients with LBBB. Left bundle branch area pacing is associated with more physiological ventricular activation.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NU21-02-00584" target="_blank" >NU21-02-00584: Ultra-high-frequency ECG for prediction of adverse left ventricular remodeling in permanent right ventricular pacing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Heart Journal Supplements

ISSN

1520-765X

e-ISSN

1554-2815

Volume of the periodical

25

Issue of the periodical within the volume

Supplement E

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

"E17"-"E24"

UT code for WoS article

001009977800004

EID of the result in the Scopus database

2-s2.0-85161054979