Left bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral wall depolarization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00544671" target="_blank" >RIV/68081731:_____/21:00544671 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075085 RIV/00216208:11120/21:43921450 RIV/00216305:26220/21:PU141465 RIV/00064173:_____/21:N0000040
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1547527121004021?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1547527121004021?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.hrthm.2021.04.025" target="_blank" >10.1016/j.hrthm.2021.04.025</a>
Alternative languages
Result language
angličtina
Original language name
Left bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral wall depolarization
Original language description
Background: Nonselective His-bundle pacing (nsHBp), nonselective left bundle branch pacing (nsLBBp), and left ventricular septal myocardial pacing (LVSP) are recognized as physiological pacing techniques. Objective: The purpose of this study was to compare differences in ventricular depolarization between these techniques using ultra-high-frequency electrocardiography (UHF-ECG). Methods: In patients with bradycardia, nsHBp, nsLBBp (confirmed concomitant left bundle branch [LBB] and myocardial capture), and LVSP (pacing in left ventricular [LV] septal position without proven LBB capture) were performed. Timings of ventricular activations in precordial leads were displayed using UHF-ECG, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. Duration of local depolarization (Vd) was determined as width of the UHF-QRS complex at 50% of its amplitude. Results: In 68 patients, data were collected during nsLBBp (35), LVSP (96), and nsHBp (55). nsLBBp resulted in larger e-DYS than did LVSP and nsHBp [– 24 ms (–28,–19) vs –12 ms (–16,–9) vs 10 ms (7,14), respectively, P <.001]. nsLBBp produced similar values of Vd in leads V5–V8 (36-43 ms vs 38-43 ms, P = NS in all leads) but longer Vd in leads V1–V4 (47–59 ms vs 41–44 ms, P <.05) as nsHBp. LVSP caused prolonged Vd in leads V1–V8 compared to nsHBp and longer Vd in leads V5–V8 compared to nsLBBp (44–51 ms vs 36–43 ms, P <.05) regardless of R-wave peak time in lead V5 or QRS morphology in lead V1 present during LVSP. Conclusion: nslbbp preserves physiological LV depolarization but increases interventricular electrical dyssynchrony. LV lateral wall depolarization during LVSP is prolonged, but interventricular synchrony is preserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NU21-02-00584" target="_blank" >NU21-02-00584: Ultra-high-frequency ECG for prediction of adverse left ventricular remodeling in permanent right ventricular pacing</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Heart Rhythm
ISSN
1547-5271
e-ISSN
1556-3871
Volume of the periodical
18
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1281-1289
UT code for WoS article
000680052000010
EID of the result in the Scopus database
2-s2.0-85106369108