Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F23%3A00571762" target="_blank" >RIV/68081731:_____/23:00571762 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43925338 RIV/00216305:26220/23:PU147997 RIV/00064173:_____/23:43925338 RIV/00159816:_____/23:00079628
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcvm.2023.1140988/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcvm.2023.1140988/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcvm.2023.1140988" target="_blank" >10.3389/fcvm.2023.1140988</a>
Alternative languages
Result language
angličtina
Original language name
Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing
Original language description
Background: Left bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal pacing with direct LBB capture (aLBBP) affects the resultant ventricular depolarization pattern. Methods: In patients with bradycardia, His bundle pacing (HBP), unipolar nonselective LBBP (nsLBBP), aLBBP, and right ventricular septal pacing (RVSP) were performed. Timing of local ventricular activation, in leads V1-V8, was displayed using UHF-ECG, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. Durations of local depolarizations were determined as the width of the UHF-QRS complex at 50% of its amplitude. Results: aLBBP was feasible in 63 of 75 consecutive patients with successful nsLBBP. aLBBP significantly improved ventricular dyssynchrony (mean9 ms, 95% CI (-12,-6) vs.24 ms (-27,-21), ), p < 0.001) and shortened local depolarization durations in V1-V4 (mean differences7 ms to5 ms (-11,-1), p < 0.05) compared to nsLBBP. aLBBP resulted in e-DYS9 ms (-12,6) vs. e-DYS 10 ms (7,14), p < 0.001 during HBP. Local depolarization durations in V1-V2 during aLBBP were longer than HBP (differences 5-9 ms (1,14), p < 0.05, with local depolarization duration in V1 during aLBBP being the same as during RVSP (difference 2 ms (-2,6), p = 0.52). Conclusion: Although aLBBP improved ventricular synchrony and depolarization duration of the septum and RV compared to unipolar nsLBBP, the resultant ventricular depolarization was still less physiological than during HBP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cardiovascular Medicine
ISSN
2297-055X
e-ISSN
2297-055X
Volume of the periodical
10
Issue of the periodical within the volume
22 March
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
1140988
UT code for WoS article
000963698000001
EID of the result in the Scopus database
2-s2.0-85152550668