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Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F23%3A00571762" target="_blank" >RIV/68081731:_____/23:00571762 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/23:43925338 RIV/00216305:26220/23:PU147997 RIV/00064173:_____/23:43925338 RIV/00159816:_____/23:00079628

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fcvm.2023.1140988/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcvm.2023.1140988/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fcvm.2023.1140988" target="_blank" >10.3389/fcvm.2023.1140988</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing

  • Original language description

    Background: Left bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal pacing with direct LBB capture (aLBBP) affects the resultant ventricular depolarization pattern. Methods: In patients with bradycardia, His bundle pacing (HBP), unipolar nonselective LBBP (nsLBBP), aLBBP, and right ventricular septal pacing (RVSP) were performed. Timing of local ventricular activation, in leads V1-V8, was displayed using UHF-ECG, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. Durations of local depolarizations were determined as the width of the UHF-QRS complex at 50% of its amplitude. Results: aLBBP was feasible in 63 of 75 consecutive patients with successful nsLBBP. aLBBP significantly improved ventricular dyssynchrony (mean9 ms, 95% CI (-12,-6) vs.24 ms (-27,-21), ), p < 0.001) and shortened local depolarization durations in V1-V4 (mean differences7 ms to5 ms (-11,-1), p < 0.05) compared to nsLBBP. aLBBP resulted in e-DYS9 ms (-12,6) vs. e-DYS 10 ms (7,14), p < 0.001 during HBP. Local depolarization durations in V1-V2 during aLBBP were longer than HBP (differences 5-9 ms (1,14), p < 0.05, with local depolarization duration in V1 during aLBBP being the same as during RVSP (difference 2 ms (-2,6), p = 0.52). Conclusion: Although aLBBP improved ventricular synchrony and depolarization duration of the septum and RV compared to unipolar nsLBBP, the resultant ventricular depolarization was still less physiological than during HBP.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Cardiovascular Medicine

  • ISSN

    2297-055X

  • e-ISSN

    2297-055X

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    22 March

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    1140988

  • UT code for WoS article

    000963698000001

  • EID of the result in the Scopus database

    2-s2.0-85152550668