Electromembrane extraction of anesthetic ketamine on-line coupled to capillary electrophoresis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43925753" target="_blank" >RIV/00216208:11120/23:43925753 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10464911
Result on the web
<a href="https://doi.org/10.1016/j.microc.2023.108886" target="_blank" >https://doi.org/10.1016/j.microc.2023.108886</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.microc.2023.108886" target="_blank" >10.1016/j.microc.2023.108886</a>
Alternative languages
Result language
angličtina
Original language name
Electromembrane extraction of anesthetic ketamine on-line coupled to capillary electrophoresis
Original language description
The anesthetic ketamine is extracted from the sample solutions by electromembrane extraction on-line coupled with capillary electrophoresis (CE) at a short separation path. Ketamine is extracted from model acidic and alkaline aqueous solutions, or from untreated human urine as donor into an acidic acceptor solution, which acts also as background electrolyte for CE. Extraction occurs in a flow-through extraction mini probe with an internal volume of 1.1 µL, consisting of a porous hollow fiber with pores filled with nitrophenyloctyl ether as extraction liquid. The probe is immersed in a 1.5 mL vial of analyte solution, the vial is vibrationally agitated during extraction, and ketamine is extracted at 150 V for 300 s. It was found that the pH of the sample solution does not affect the extraction efficiency, i.e., it does not depend on whether ketamine is in the protonated form or as a neutral molecule during extraction; the enrichment factor is 16-19, the recovery factor 1.5 %. The calibration dependence is linear in both model samples in the concentration range 2 to 50 µM and in urine in the concentration range 2.5 to 10 µM with the same slope in both sample types. The LOD values are around 1 µM. The extraction probe is reusable. However, between runs a purification process with the probe immersed in the background electrolyte is necessary to remove ketamine trapped in the membrane liquid.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
<a href="/en/project/GA22-22398S" target="_blank" >GA22-22398S: Microfluidic and electronic devices for on-line electrophoretic analysis of adipose tissue</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microchemical Journal
ISSN
0026-265X
e-ISSN
1095-9149
Volume of the periodical
191
Issue of the periodical within the volume
August
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
108886
UT code for WoS article
001008669600001
EID of the result in the Scopus database
2-s2.0-85160063051