Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F10%3A6286" target="_blank" >RIV/00216208:11130/10:6286 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/10:00349066

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

Original language description

The authors address the issues of drug design and specificity and focus the discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR in the following topics: (i) the role of oxytocin in behavior and affectivity, (ii) the relationship between oxytocin and stress with emphasis on the hypothalamo-pituitary-adrenal axis, (iii) the involvement of oxytocin in pain regulation and nociception, (iv) the specific action mechanisms of oxytocin on intracellular Ca2+ in the hypothalamo neurohypophysial system (HNS) cell bodies, (v) newly generated transgenic rats tagged by a visible fluorescent protein to study the physiology of vasopressin and oxytocin, and (vi) the action of the neurohypophysial hormone outside the central nervous system, including the myometrium, heart and peripheral nervous system. Understanding the fundamental physiopharmacology of the effects of oxytocin is an important and necessary approach for developing a potential pharmacotherapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CNS Neuroscience & Therapeutics

ISSN

1755-5930

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

19

Pages from-to

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UT code for WoS article

000281643500001

EID of the result in the Scopus database

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