Í-opioid receptor modulation of Oxytocin and Vasopressin release in the Hypothalamic-Neurohypophysial System
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00383990" target="_blank" >RIV/68378041:_____/12:00383990 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Í-opioid receptor modulation of Oxytocin and Vasopressin release in the Hypothalamic-Neurohypophysial System
Original language description
The Hypothalamic-Neurohypophysial System (HNS) in mammals controls diuresis and parturition through the release of the neuropeptides arginine-vasopressin (AVP) and oxytocin (OT). Neuroendocrine function in the HNS is modulated by opioids, either releasedendogenously or applied exogenously, by acting on mí- or kappa-selective opioid receptors. In the present research, we characterized the expression of both mí or kappa-opioid receptors and voltage-gated calcium channels (VGCC) and provide evidence for adifferential targeting of channels in OT vs. AVP nerve terminals. We propose a model that can explain how opiate effects on VGCCs can directly mediate differences in the control of neurohypophysial OT and/or AVP release.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Opioids: Pharmacology, Clinical Uses and Adverse Effects
ISBN
978-1-61942-101-1
Number of pages of the result
24
Pages from-to
35-58
Number of pages of the book
130
Publisher name
Nova Science Publishers, Inc
Place of publication
New York
UT code for WoS chapter
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