DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (Tp53, p21(CDKNIA), BCL2 and BAX) with respect to occupational exposure to styrene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A6989" target="_blank" >RIV/00216208:11130/11:6989 - isvavai.cz</a>

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/20966084" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/20966084</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (Tp53, p21(CDKNIA), BCL2 and BAX) with respect to occupational exposure to styrene

Original language description

We studied the relationship between DNA damage, DNA repair rates and messenger RNA (mRNA) expression levels of cell cycle genes TP53, p21(CDKNIA), BCL2 and BAX in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessedby measuring the concentration of styrene at workplace and in blood. Parameters of DNA damage [measured as single-strand breaks (SSBs) and endonuclease III-sensitive sites], gamma-irradiation-specific DNA repair rates and mRNA levels of studied genes were analyzed in peripheral blood lymphocytes. The workers were divided into low (<50 mg/m(3)) and high (>50 mg/m(3)) styrene exposure groups. We found negative correlations between mRNA expression of TP53, BCL2, BAX and styrene exposure (P < 0.001 for allparameters). In contrast, p21(CDKNIA) mRNA expression significantly increased with increasing styrene exposure (P = 0.001). SSBs and endonuclease Insensitive sites increased with increasing mRNA levels of TP53 (P < 0.001 for both) and BC

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

74-79

UT code for WoS article

000286303000012

EID of the result in the Scopus database

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