DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002563" target="_blank" >RIV/60162694:G44__/11:00002563 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/carcin/bgq213" target="_blank" >http://dx.doi.org/10.1093/carcin/bgq213</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes
Original language description
We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNAdamage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XR
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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