Astroglial networks scale synaptic activity and plasticity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7019" target="_blank" >RIV/00216208:11130/11:7019 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00359930 RIV/68378041:_____/11:00387965
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21536893" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21536893</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Astroglial networks scale synaptic activity and plasticity
Original language description
Astrocytes dynamically interact with neurons to regulate synaptic transmission. Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic physiology is unknown. Here we show, by inactivating Cx30 and Cx43 genes, that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. This regulation limits neuronal excitability, release probability, and insertion of postsynaptic AMPA receptors, silencing synapses. By controlling synaptic strength,connexins play an important role in synaptic plasticity. Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
108
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
8467-8472
UT code for WoS article
000290719600076
EID of the result in the Scopus database
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