Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7058" target="_blank" >RIV/00216208:11130/11:7058 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/11:00002478
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21411763" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21411763</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats
Original language description
Alterations in renal function contribute to Goldblatt two-kidney, one-clip (2K1C) hypertension. A previous study indicated that bioavailability of cytochrome P-450 metabolites epoxyeicosatrienoic acids (EETs) is decreased while that of 20-hydroxyeicosatetraenoic acids (20-HETE) is increased in this model. We utilized the inhibitor of soluble epoxide hydrolase cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (c-AUCB) and HET-0016, the inhibitor of 20-HETE production, to study the role of EETs and 20-HETE in the regulation of renal function. Chronic c-AUCB treatment significantly decreased systolic blood pressure (SBP) (133 +/- 1 vs. 163 +/- 3 mmHg) and increased sodium excretion (1.23 +/- 0.10 vs. 0.59 +/- 0.03 mmol/day) in 2K1C rats. HET-0016 did not affect SBP and sodium excretion. In acute experiments, renal blood flow (RBF) was decreased in 2K1C rats (5.0 +/- 0.2 vs. 6.9 +/- 0.2 ml.min(-1).g(-1)). c-AUCB normalized RBF in 2K1C rats (6.5 +/- 0.6 ml.min(-1).g(-1)). HET-0
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology-Regulatory Integrative and Comparative Physiology
ISSN
0363-6119
e-ISSN
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Volume of the periodical
300
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"R1468"-"R1475"
UT code for WoS article
000291532000025
EID of the result in the Scopus database
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