Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal reninangiotensin system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209764" target="_blank" >RIV/00216208:11130/13:10209764 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/13:00058540
Result on the web
<a href="http://dx.doi.org/10.1111/1440-1681.12018" target="_blank" >http://dx.doi.org/10.1111/1440-1681.12018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.12018" target="_blank" >10.1111/1440-1681.12018</a>
Alternative languages
Result language
angličtina
Original language name
Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal reninangiotensin system
Original language description
The aim of the present study was to evaluate the hypothesis that the antihypertensive effects of inhibition of soluble epoxide hydrolase (sEH) are mediated by increased intrarenal availability of epoxyeicosatrienoic acids (EETs), with consequent improvement in renal haemodynamic autoregulatory efficiency and the pressurenatriuresis relationship. Ren-2 transgenic rats (TGR), a model of angiotensin (Ang) II-dependent hypertension, and normotensive transgene-negative Hannover SpragueDawley (HanSD) rats were treated with the sEH inhibitor cis-4-(4-(3-adamantan-1-yl-ureido)cyclohexyloxy)benzoic acid (c-AUCB; 26mg/L) for 48h. Then, the effects on blood pressure (BP), autoregulation of renal blood flow (RBF) and glomerular filtration rate (GFR), and on the pressurenatriuresis relationship in response to stepwise reductions in renal arterial pressure (RAP) were determined. Treatment with c-AUCB did not significantly change BP, renal autoregulation or pressure-natriuresis in normotensive HanSD
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
O - Projekt operacniho programu
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Pharmacology and Physiology
ISSN
0305-1870
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
4
Country of publishing house
AU - AUSTRALIA
Number of pages
9
Pages from-to
273-281
UT code for WoS article
000316914700004
EID of the result in the Scopus database
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