Fluorescent magnetic nanoparticles for biomedical applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7084" target="_blank" >RIV/00216208:11130/11:7084 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00359777 RIV/61389013:_____/11:00359777 RIV/00023001:_____/11:00002740
Result on the web
<a href="http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10621j" target="_blank" >http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10621j</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fluorescent magnetic nanoparticles for biomedical applications
Original language description
The simultaneous combination of optical and magnetic resonance imaging (MRI) would greatly benefit in vivo disease diagnosis as well as in situ monitoring of living cells. In order to design dual detection of cells involving simultaneous imaging by fluorescent microscopy and MRI, nanoparticles with two reporters, a fluorescent dye and a superparamagnetic core, included in one particle were synthesized and characterized. The gamma-Fe2O3 nanoparticles obtained by coprecipitation and oxidation were coatedwith silica (SiO2) or carboxymethyl chitosan (CMCS) and labeled with fluorescein isothiocyanate (FITC). The fluorescent label was covalently bound to the nanoparticles and was not quenched by the iron oxide core. The nanoparticles successfully labeled rat mesenchymal stem cells (rMSCs) in vitro. Relaxation time measurements found large amounts of iron inside the cells with FITC-labeled gamma-Fe2O3-SiO2-AP nanoparticles. Both MR and fluorescent imaging of a rat brain with implanted rMSCs
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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