Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7095" target="_blank" >RIV/00216208:11130/11:7095 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/11:00368248

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21736505" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21736505</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

Original language description

Background aims. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of brain and spinal cord motor neurons (MN). The intraspinal and systemic grafting of mesenchymal stromal cells (MSC) was used to treat symptomatic transgenic rats overexpressing human superoxide dismutase 1 (SOD1) in order to alleviate the disease course and prolong the animals 'lifespan. Methods. At the age of 16 weeks (disease onset) the rats received two grafts of MSC expressinggreen fluorescent protein (GFP(+) MSC) on the same day, intraspinally (10(5) cells) and intravenously (2 x 10(6) cells). Sham-treated animals were injected with phosphate-buffered saline (PBS). Motor activity, grip strength and body weight were tested,followed by immunohistochemical analysis. Results. The combined grafting of MSC into symptomatic rats had a significant effect on motor activity and grip strength starting 4 weeks after transplantation. The lifespan of animals in the trea

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytotherapy

ISSN

1465-3249

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

9

Country of publishing house

NO - NORWAY

Number of pages

11

Pages from-to

1036-1046

UT code for WoS article

000294904300003

EID of the result in the Scopus database

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