Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7126" target="_blank" >RIV/00216208:11130/11:7126 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/11:00002526

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/22099763" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/22099763</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats

Original language description

Background. The transplantation of islets of Langerhans isolated from one donor pancreas can rarely release a diabetic recipient from insulin injections. The major reason is the destruction of 50%-60% of the transplanted tissue, which proceeds typicallywithin a few hours after the insertion of the islets into the portal vein. Therefore, several groups have focused on development of an artificial site for islet transplantation. The main aim of the present study was to test the efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate the blood supply feeding the artificially created cavities for islet transplantation. Methods. Two rounded devices were implanted: one device subcutaneously and the second one into the greateromentum of each animal. On the day of implantation as well as 1, 3, and 4 weeks later, we quickly injected the vascular specific MR contrast agent Vasovist (0.05 mL/100 g) intravenously. Penetration of the contrast agent was monitored by

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/GP303%2F09%2FP200" target="_blank" >GP303/09/P200: The inhibition of tissue factor expression by cells of isolated pancreatic islets using RNA interference</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

3226-3230

UT code for WoS article

000297485500020

EID of the result in the Scopus database

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