The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8166" target="_blank" >RIV/00216208:11130/12:8166 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/12:00377854 RIV/68378041:_____/12:00377854
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0039959" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0039959</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia
Original language description
The expression of TRPV4 is markedly enhanced in adult rat hippocampal astrocytes of the CA1 region after hypoxia/ischemia coinciding with the development of astrogliosis. This was revealed by immunohistochemical analyses, patch-clamp and calcium imagingmeasurements both in vitro and in situ. Collectively, we show that TRPV4 channels are involved in ischemia induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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