A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10196805" target="_blank" >RIV/00216208:11130/13:10196805 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00424945 RIV/68378041:_____/13:00397648 RIV/67985904:_____/13:00397648 RIV/68407700:21460/13:00217071 and 2 more
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpharm.2013.02.056" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2013.02.056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2013.02.056" target="_blank" >10.1016/j.ijpharm.2013.02.056</a>

Result language
angličtina
Original language name
A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs
Original language description
The aim of the study was to evaluate the effect of a cell-free hyaluronate/type I collagen/fibrin composite scaffold containing polyvinyl alcohol (PVA) nanofibers enriched with liposomes, basic fibroblast growth factor (bFGF) and insulin on the regeneration of osteochondral defects. A novel drug delivery system was developed on the basis of the intake effect of liposomes encapsulated in PVA nanofibers. Time-controlled release of insulin and bFGF improved MSC viability in vitro. Nanofibers functionalizedwith liposomes also improved the mechanical characteristics of the composite gel scaffold. In addition, time-controlled release of insulin and bFGF stimulated MSC recruitment from bone marrow in vivo. Cell-free composite scaffolds containing PVA nanofibers enriched with liposomes, bFGF, and insulin were implanted into seven osteochondral defects of miniature pigs. Control defects were left untreated. After 12 weeks, the composite scaffold had enhanced osteochondral regeneration towards
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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