Special nanofiber scaffold designed for cellular products in the treatment of chronic wounds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F64577732%3A_____%2F20%3AN0000001" target="_blank" >RIV/64577732:_____/20:N0000001 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/21:00354514

Result on the web

<a href="https://www.confer.cz/nanocon/2020/3753-special-nanofiber-scaffold-designed-for-cellular-products-in-the-treatment-of-chronic-wounds" target="_blank" >https://www.confer.cz/nanocon/2020/3753-special-nanofiber-scaffold-designed-for-cellular-products-in-the-treatment-of-chronic-wounds</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2020.3753" target="_blank" >10.37904/nanocon.2020.3753</a>

Result language

angličtina

Original language name

Special nanofiber scaffold designed for cellular products in the treatment of chronic wounds

Original language description

In this work we have prepared and characterized several types of nanofibers to create unique nanofiber substrates as a medical device for long-term non-healing wound treating using cellular products. Our nanofibers are based on biodegradable polymers such as polycaprolactone (PCL), poly(lactide-co-caprolactone) (PLCL), poly(vinyl)alcohol (PVA), polyethyleneimine (PEI) and hyaluronic acid. Prepared nanofiber carriers were specifically adjusted for the autologous MSCs (mesenchymal stromal cells) applications on the chronic wound. In addition, the nanofiber sheets were constructed as a biodegradable material to guarantee proper timing of its resorption in a chronic wound during the healing process. Furthermore, the effect of growth factors on MSC proliferation was tested. The release of bFGF from adsorbed lipid particles was tested. The results show increased proliferation of MSCs. Despite fast increasing advanced technologies in healthcare, chronic wound treating tends to be still very difficult and challenging. Our developed nanofiber-based dressings are very promising for poorly healing wound therapy using MSCs. The main goal is to make chronic wound healing more effective and decrease a time of healing process. This work was performed as part of the project FV20422 "Development of nanofibrous scaffolds ensuring application of cellular products, including physical stimulation effect, with the intended purpose of the treatment of chronic wounds".

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

<a href="/en/project/FV20422" target="_blank" >FV20422: Development of nanofibrous scaffolds ensuring application of cellular products, including physical stimulation effect, with the intended purpose of the treatment of chronic wounds.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings 12th International Conference on Nanomaterials - Research & Application

ISBN

978-80-87294-98-7

ISSN

2694-930X

e-ISSN

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Number of pages

7

Pages from-to

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Publisher name

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Place of publication

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Event location

Brno

Event date

Jan 1, 2020

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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