Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209622" target="_blank" >RIV/00216208:11130/13:10209622 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00394051
Result on the web
<a href="http://dx.doi.org/10.1016/j.nbd.2013.02.001" target="_blank" >http://dx.doi.org/10.1016/j.nbd.2013.02.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nbd.2013.02.001" target="_blank" >10.1016/j.nbd.2013.02.001</a>

Result language
angličtina
Original language name
Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy
Original language description
Temporal lobe epilepsy alters adult neurogenesis. Existing experimental evidence is mainly from chronic models induced by an initial prolonged status epilepticus associated with substantial cell death. In these models, neurogenesis increases after statusepilepticus. To test whether status epilepticus is necessary for this increase, we examined precursor cell proliferation and neurogenesis after the onset of spontaneous seizures in a model of temporal lobe epilepsy induced by unilateral intrahippocampalinjection of tetanus toxin, which does not cause status or, in most cases, detectable neuronal loss. We found a 4.5 times increase in BrdU labeling (estimating precursor cells proliferating during the 2nd week after injection of toxin and surviving at least up to 7 days) in dentate gyri of both injected and contralateral hippocampi of epileptic rats. Radiotelemetry revealed that the rats experienced 112+/-24 seizures, lasting 88+/-11 s each, over a period of 8.6+/-1.3 days from the firs
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F10%2F0999" target="_blank" >GAP303/10/0999: The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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