Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00439333" target="_blank" >RIV/67985823:_____/14:00439333 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neuroscience.2014.03.013" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2014.03.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuroscience.2014.03.013" target="_blank" >10.1016/j.neuroscience.2014.03.013</a>

Result language
angličtina
Original language name
Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain
Original language description
In this study we examined whether the level or distribution of a2d-1 was altered in the hippocampus following experimental induction of epileptic seizures in rats, using both the kainic acid model of human temporal lobe epilepsy, in which status epilepticus is induced, and the tetanus toxin model in which status epilepticus is not involved. The main finding of this study is that we did not identify somatic overexpression of a2d-1 in hippocampal neurons in either of the epilepsy models, unlike the upregulation of a2d-1 that occurs following peripheral nerve damage to both somatosensory and motor neurons
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NT14489" target="_blank" >NT14489: Understanding of functional organization of temporal lobe epilepsy neuronal networks</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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