Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209656" target="_blank" >RIV/00216208:11130/13:10209656 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00397661
Result on the web
<a href="http://dx.doi.org/10.2217/NNM.12.140" target="_blank" >http://dx.doi.org/10.2217/NNM.12.140</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/NNM.12.140" target="_blank" >10.2217/NNM.12.140</a>
Alternative languages
Result language
angličtina
Original language name
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
Original language description
Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factorsnecessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell na
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
1137-1154
UT code for WoS article
000320853500017
EID of the result in the Scopus database
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