Synchronization and desynchronization in epilepsy: controversies and hypotheses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209665" target="_blank" >RIV/00216208:11130/13:10209665 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00391831
Result on the web
<a href="http://dx.doi.org/10.1113/jphysiol.2012.239590" target="_blank" >http://dx.doi.org/10.1113/jphysiol.2012.239590</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1113/jphysiol.2012.239590" target="_blank" >10.1113/jphysiol.2012.239590</a>
Alternative languages
Result language
angličtina
Original language name
Synchronization and desynchronization in epilepsy: controversies and hypotheses
Original language description
Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11460" target="_blank" >NT11460: Intracranial EEG signal processing; epileptogenic zone identification in non-lesional refractory epilepsy patients</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology
ISSN
0022-3751
e-ISSN
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Volume of the periodical
591
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
787-797
UT code for WoS article
000315150000007
EID of the result in the Scopus database
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