Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10383559" target="_blank" >RIV/00216208:11130/18:10383559 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/18:00498725 RIV/67985807:_____/18:00498725 RIV/68407700:21230/18:00324487
Result on the web
<a href="https://doi.org/10.1038/s41593-018-0278-y" target="_blank" >https://doi.org/10.1038/s41593-018-0278-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41593-018-0278-y" target="_blank" >10.1038/s41593-018-0278-y</a>

Result language
angličtina
Original language name
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Original language description
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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