The Impact of Alpha-Syntrophin Deletion on the Changes in Tissue Structure and Extracellular Diffusion Associated with Cell Swelling under Physiological and Pathological Conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209729" target="_blank" >RIV/00216208:11130/13:10209729 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00395418
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0068044" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0068044</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0068044" target="_blank" >10.1371/journal.pone.0068044</a>
Alternative languages
Result language
angličtina
Original language name
The Impact of Alpha-Syntrophin Deletion on the Changes in Tissue Structure and Extracellular Diffusion Associated with Cell Swelling under Physiological and Pathological Conditions
Original language description
Aquaporin-4 (AQP4) is the primary cellular water channel in the brain and is abundantly expressed by astrocytes along the blood-brain barrier and brain-cerebrospinal fluid interfaces. Water transport via AQP4 contributes to the activity-dependent volumechanges of the extracellular space (ECS), which affect extracellular solute concentrations and neuronal excitability. AQP4 is anchored by alpha-syntrophin (alpha-syn), the deletion of which leads to reduced AQP4 levels in perivascular and subpial membranes. We used the real-time iontophoretic method and/or diffusion-weighted magnetic resonance imaging to clarify the impact of alpha-syn deletion on astrocyte morphology and changes in extracellular diffusion associated with cell swelling in vitro and in vivo. In mice lacking alpha-syn, we found higher resting values of the apparent diffusion coefficient of water (ADC(W)) and the extracellular volume fraction (alpha). No significant differences in tortuosity (lambda) or non-specific uptake
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
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UT code for WoS article
000321425300037
EID of the result in the Scopus database
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