Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209740" target="_blank" >RIV/00216208:11130/13:10209740 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00396554 RIV/00023001:_____/13:00058650
Result on the web
<a href="http://dx.doi.org/10.1186/scrt219" target="_blank" >http://dx.doi.org/10.1186/scrt219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/scrt219" target="_blank" >10.1186/scrt219</a>
Alternative languages
Result language
angličtina
Original language name
Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat
Original language description
A conditionally immortalized neural stem cell line derived from human fetal spinal cord tissue (SPC-01) was used to treat a balloon-induced SCI. SPC-01 cells were implanted into the lesion 1 week after SCI. To determine the feasibility of tracking transplanted stem cells, a portion of the SPC-01 cells was labeled with poly-L-lysine-coated superparamagnetic iron-oxide nanoparticles, and the animals grafted with labeled cells underwent magnetic resonance imaging. Functional recovery was evaluated by usingthe BBB and plantar tests, and lesion morphology, endogenous axonal sprouting and graft survival, and differentiation were analyzed. Quantitative polymerase chain reaction (qPCR) was used to evaluate the effect of transplanted SPC-01 cells on endogenousregenerative processes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Research and Therapy
ISSN
1757-6512
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
neuveden
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
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UT code for WoS article
000320782300001
EID of the result in the Scopus database
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