Treating spinal cord injury in rats with a combination of human fetal neural stem cells and hydrogels modified with serotonin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10209692" target="_blank" >RIV/00216208:11310/13:10209692 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/13:10209692 RIV/68378041:_____/13:00396614 RIV/61389013:_____/13:00396614 RIV/44555601:13440/13:43884965

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Treating spinal cord injury in rats with a combination of human fetal neural stem cells and hydrogels modified with serotonin

Original language description

Currently, there is no effective strategy for the treatment of spinal cord injury (SCI). A combination of biomaterials and stem cell therapy seems to be a promising approach to increase regenerative potential after SCI. We evaluated the use of a cell-polymer construct based on a combination of the conditionally immortalized spinal progenitor cell line SPC-01_GFP3, derived from human fetal spinal cord tissue, with a serotonin-modified poly(2-hydroxyethyl methacrylate) hydrogel (pHEMA-5HT). We compared the effect of treatment with a pHEMA-5HT hydrogel seeded with SPC-01 _GFP3 cells, treatment with a pHEMA-5HT only and no treatment on functional outcome and tissue reconstruction in hemisected rats. Prior to transplantation the cell-polymer construct displayed a high potential to support the growth, proliferation and differentiation of SPC-01 cells in vitro. One month after surgery, combined hydrogel-cell treatment reduced astrogliosis and tissue atrophy and increased axonal and blood vess

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurobiologiae Experimentalis

ISSN

0065-1400

e-ISSN

—

Volume of the periodical

73

Issue of the periodical within the volume

1

Country of publishing house

IN - INDIA

Number of pages

14

Pages from-to

102-115

UT code for WoS article

000318197900008

EID of the result in the Scopus database

—