Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209785" target="_blank" >RIV/00216208:11130/13:10209785 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/13:10209785
Result on the web
<a href="http://dx.doi.org/10.1007/s00467-012-2332-4" target="_blank" >http://dx.doi.org/10.1007/s00467-012-2332-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00467-012-2332-4" target="_blank" >10.1007/s00467-012-2332-4</a>
Alternative languages
Result language
angličtina
Original language name
Late recovery of renal function by rituximab in a patient with Wegener's granulomatosis
Original language description
Rituximab has proven effective in the treatment of complicated granulomatosis with polyangiitis (Wegener's, GPA). Two controlled trials in adults demonstrated beneficial effects of rituximab compared to cyclophosphamide in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis to induce remission and to treat relapses. Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown. We report a female adolescent with GPA and necrotizing glomerulonephritis that lead to end-stage renal disease (ESRD). After 22 months of peritoneal dialysis, she still experienced relapses and major treatment-associated adverse effects. After a single dose of rituximab, she rapidly achieved clinical remission and, unexpectedly, steadily recovered glomerular filtration rate, plateauing at 25 ml/min/1.73 m(2). Peritoneal dialysis could be discontinued for 16 months. This case documents a potent beneficial effect of rituximab on renal manifestation of GPA even in long-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Nephrology
ISSN
0931-041X
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
511-514
UT code for WoS article
000314038000020
EID of the result in the Scopus database
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