L-Arginine in Combination With Sildenafil Potentiates the Attenuation of Hypoxic Pulmonary Hypertension in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209800" target="_blank" >RIV/00216208:11130/13:10209800 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058762

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/62/62_589.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/62/62_589.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

L-Arginine in Combination With Sildenafil Potentiates the Attenuation of Hypoxic Pulmonary Hypertension in Rats

Original language description

Chronic hypoxia induces an increased production of nitric oxide (NO) in pulmonary prealveolar arterioles. Bioavailability of the NO in the pulmonary vessels correlates with concentration of L-arginine as well as activity of phosphodiesterase-5 enzyme (PDE-5). We tested a hypothesis whether a combination of L-arginine and PDE-5 inhibitor sildenafil has an additive effect in reduction of the hypoxic pulmonary hypertension (HPH) in rats. Animals were exposed to chronic normobaric hypoxia for 3 weeks. In the AH group, rats were administered L-arginine during chronic hypoxic exposure. In the SH group, rats were administered sildenafil during chronic hypoxic exposure. In the SAH group, rats were treated by the combination of L-arginine as well as sildenafilduring exposure to chronic hypoxia. Mean PAP, structural remodeling of peripheral pulmonary arterioles (%DL) and RV/LV+S ratio was significantly decreased in the SAH group compared to hypoxic controls even decreased compared to the AH and

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

589-595

UT code for WoS article

000329167600001

EID of the result in the Scopus database

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