Remodeling of fetoplacental arteries in rats due to chronic hypoxia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10193795" target="_blank" >RIV/00216208:11130/13:10193795 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/13:10193795

Result on the web

<a href="http://dx.doi.org/10.1016/j.etp.2011.06.006" target="_blank" >http://dx.doi.org/10.1016/j.etp.2011.06.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etp.2011.06.006" target="_blank" >10.1016/j.etp.2011.06.006</a>

Result language

angličtina

Original language name

Remodeling of fetoplacental arteries in rats due to chronic hypoxia

Original language description

The increased fetoplacental vascular resistance due to chronic hypoxia cannot be explained by simple hypoxic vasoconstriction, as it sustains to some degree after recovery in normobaric environment. To verify a hypothesis that fetoplacental arteries undergo remodeling of their walls similar to remodeling of pulmonary arteries in hypoxic pulmonary hypertension, we used a model of the chronically hypoxic rat placenta. Han Wistar pregnant rats were exposed to 14-day hypoxia (10% of oxygen) during the 6th to 19th day of pregnancy. Chronic hypoxia elicited in both intraplacental (prelabyrinthine) and chorionic plate (insertion) arteries significant narrowing of their lumina. Irregular thickening of their adventitia due to an increase in collagen fibers as well as ground substance was observed; reticular fibers were fragmented. Because of remodeling of fetoplacental arteries, a model of chronically hypoxic rat placenta could simulate human preplacental hypoxia and consequent effects.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Toxicologic Pathology

ISSN

0940-2993

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

97-103

UT code for WoS article

000314006000016

EID of the result in the Scopus database

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