Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10210371" target="_blank" >RIV/00216208:11130/13:10210371 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00392836
Result on the web
<a href="http://link.springer.com/chapter/10.1007/978-1-4614-5203-4_6" target="_blank" >http://link.springer.com/chapter/10.1007/978-1-4614-5203-4_6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4614-5203-4_6" target="_blank" >10.1007/978-1-4614-5203-4_6</a>
Alternative languages
Result language
angličtina
Original language name
Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia
Original language description
One of the most common insults during early stages of postnatal ontogenetic development is hypoxemia due to cyanotic congenital heart defects. The question of the presumed cardiac impact will be, therefore, of considerable importance. Experimental results have clearly shown that the immature heart is significantly more tolerant to acute oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac mitochondrial function and energy metabolism. Adaptation to chronic hypoxia confers long-lasting protection in both adult and immature heart. However, the already high resistance of the newborn heart cannot be further increased;the effects of protective mechanisms appear only when the ischemic tolerance starts to decrease during development. Early chronic hypoxia, although transient, may have serious sex-dependent late consequences on the adult cardiovascular s
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interaction between sustained forms of cardioprotection induced by adaptation to chronic hypoxia and regular exercise training.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Cardiac Adaptations
ISBN
978-1-4614-5202-7
Number of pages of the result
12
Pages from-to
99-110
Number of pages of the book
402
Publisher name
Springer Science+Bussines
Place of publication
USA
UT code for WoS chapter
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