The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10210476" target="_blank" >RIV/00216208:11130/13:10210476 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/13:10210476
Result on the web
<a href="http://www.ibimapublishing.com/journals/IMMU/2013/119348/119348.pdf" target="_blank" >http://www.ibimapublishing.com/journals/IMMU/2013/119348/119348.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5171/2013.119348" target="_blank" >10.5171/2013.119348</a>
Alternative languages
Result language
angličtina
Original language name
The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
Original language description
The article gives overview of both surface and intracellular markers present on T regulatory lymphocytes. Regulatory T cells (Tregs) play a proncipal role in immune reactions including autoimmunity, transplantation tolerance, anti-infectious immunity andcancer. Today the most widely accepted phenotype for Tregs is the coexpression of CD4, CD25 and FoxP3. But FoxP3 is an intracellular molecule, detection of which requires, fixation and permeabilization of cells and the fixed cells cannot be used in studies of Treg function. Moreover intracellular FofP3 staining is hardly usable on a daily clinical routine basis. Therefore several attempts have been characterize TRgs according their surface molecules. The particular molecules like CD25, CD127, CD26, CD39, CD45RA, CD49d, CD101, CD194 are described and their significance for distinguishing T regulatory lymphocytes from other T cells is discussed. Recently described surface molecule CD26 is another negative marker which seems to improve ou
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Research in Immunology: An International Journal
ISSN
2331-7299
e-ISSN
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Volume of the periodical
2013
Issue of the periodical within the volume
neuveden
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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