Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10292823" target="_blank" >RIV/00216208:11130/14:10292823 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00428432

Result on the web

<a href="http://dx.doi.org/10.1016/j.neulet.2014.01.057" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2014.01.057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2014.01.057" target="_blank" >10.1016/j.neulet.2014.01.057</a>

Result language

angličtina

Original language name

Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats

Original language description

The perinatal hypoxic-ischemic insult frequently leads to mortality, morbidity and plays a key role in the later pathological consequences. The ischemic insult causes a massive release of glutamate and subsequent excitotoxic damage. The neuroactive steroid 3 alpha 5 beta-pregnanolone glutamate (PG) is a NMDA receptor antagonist acting via use-dependent mechanism and can be used as a neuroprotective agent that may alleviate glutamatergic excitotoxicity in the brain. First, a possible neurotoxic effect ofthe PG, a novel use-dependent NMDA antagonist, was studied in immature rats. In addition, to compare this effect with a well-described non-competitive NMDA antagonist, the MK-801 (positive control) was used. Animals at postnatal day 12 (P12) were injected intraperitoneally with PG in a doses 1 or 10 mg/kg or with MK-801 in a dose 1 mg/kg. Effect of PG treatment on the immature brain was evaluated on Fluoro Jade B (FJB) stained sections. Second, a neuroprotective effect of the PG was stu

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

564

Issue of the periodical within the volume

neuveden

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

11-15

UT code for WoS article

000334985700003

EID of the result in the Scopus database

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