Lipophilic fluorescent products of free radicals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293071" target="_blank" >RIV/00216208:11130/14:10293071 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00439228
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2012.112" target="_blank" >http://dx.doi.org/10.5507/bp.2012.112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.112" target="_blank" >10.5507/bp.2012.112</a>
Alternative languages
Result language
angličtina
Original language name
Lipophilic fluorescent products of free radicals
Original language description
Background. Fluorescent pigments are the end-products of reactions involving free radical attack on biological molecules and can be formed, for example, in reactions between lipid peroxidation products, mainly unsaturated aldehydes, with free amino groups. Their characteristic emission maximum was found to be at 420-470 nm after being excited at 340-390 nm. The mechanism of their formation and chemical identity has been revealed in many in vitro studies, in which reactive aldehydes were incubated with amino group-containing molecules. Owing to their intrinsic fluorescent properties and molecular stability these products are easily measured by means of spectrofluorimetry and are used as biomarkers of oxidative stress caused by various triggers. It has been found that the fluorescent products are formed in excess in conditions linked with increased free radical production, such as atherosclerosis, Alzheimer's disease and multiple sclerosis. Methods. We searched the literature using "MEDL
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F11%2F0298" target="_blank" >GAP303/11/0298: Biochemical and morphological aspects of early postnatal development of rat heart and brain. The role of free radicals.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
158
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
365-372
UT code for WoS article
000345398500006
EID of the result in the Scopus database
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